Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues

Calorie Restriction, Longevity and Cognitive Function

The effects of graded levels of calorie restriction: V. Impact of short term calorie and protein restriction on physical activity in the C57BL/6 mouse

Calorie restriction (CR) delays the onset of age-related disease and extends lifespan in a number of species. When faced with reduced energy supply animals need to lower energy demands, which may be achieved in part by reducing physical activity (PA). We monitored changes in PA using implanted transmitters in male C57BL/6 mice in response to graded levels of CR (10 to 40%) or matched levels of ...

The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse

Faced with reduced levels of food, animals must adjust to the consequences of the shortfall in energy. We explored how C57BL/6 mice withdrew energy from different body tissues during three months of food restriction at graded levels up to 40% (calorie restriction: CR). We compared this to the response to equivalent levels of protein restriction (PR) without a shortfall in calories. Under CR the...

Relative V # Transcript Levels in Thymus and Peripheral Lymphoid Tissues from Various Mouse Strains

Lymphocytes recognize foreign antigens via a variety of cell surface receptor glycoproteins . B lymphocyte antigen receptors can bind free antigens, in contrast to TCR, which recognize antigenic peptides in the context of molecules coded by the MHC. This phenomena is known as MHC restriction (1-3) . Biochemical studies on antigen presentation indicate that MHC molecules present fragments ofproc...

The effects of graded levels of calorie restriction: VIII. Impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse

Under calorie restriction (CR) animals need to lower energy demands. Whether this involves a reduction in cellular metabolism is an issue of contention. We exposed C57BL/6 mice to graded CR for 3 months, measured BMR and dissected out 20 body compartments. From a separate age-matched group (n=57), we built 7 predictive models for BMR. Unadjusted BMR declined with severity of restriction. Compar...